Bryan Johnson, the Silicon Valley entrepreneur, takes an extensive daily regimen of over 100 pills, which can be broken down into three categories¹: 1. **Longevity Supplements**: - **Calcium Alpha-ketoglutarate (Ca-AKG)**: He takes 2 grams daily, as it improved frailty index and increased lifespan in mice. - **Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)**: These are taken to raise NAD levels for potential longevity benefits. - **Taurine**: He consumes 2 grams daily, which has been associated with increased lifespan in mice. - **Nordihydroguaiaretic Acid (NDGA)**: He takes 50 mg, also linked to increased lifespan in mice. - **Aspirin**: He takes 81 mg three times a week, possibly due to increased longevity in mouse studies and potential cardiovascular benefits. 2. **Supplements for Specific Issues**: - **Ashwagandha**: He takes 600 mg for reduced anxiety, improved cortisol management, better sleep, and increased testosterone. - **BroccoMax / Sulforaphane**: He consumes 17.5 mg, which likely provides chemoprotection. - **Cocoa Flavanols**: He takes 500 mg for heart and brain health. 3. **Supplements to Offset Dietary Insufficiencies**: - These include B vitamins, omega-3 fatty acids, and other compounds to maintain overall health. Additionally, Bryan Johnson takes four prescription drugs: - **Acarbose**: Used for hypothyroidism. - **Metformin**: For blood sugar control. - **Rapamycin**: Taken every two weeks. - **17-Alpha Estradiol**: Used weekly⁹. Keep in mind that his regimen is highly personalized and based on scientific evidence and individual health considerations. 😊🌿 Source : conversation avec Copilot, 12/06/2024 (1) Bryan Johnson’s Supplement List - Why He Takes All 40 Daily (over 100 .... https://fastlifehacks.com/bryan-johnsons-supplement-list/. (2) Bryan Johnson’s Prescription Drugs – What He Uses & Why. https://fastlifehacks.com/bryan-johnsons-prescription-drugs-what-he-uses-why/. (3) Bryan Johnson’s Prescription Drugs – What He Uses & Why. https://bing.com/search?q=which+sort+of+pills+does+bryan+johnson+takes. (4) The Insider’s Guide to Bryan Johnson’s Supplement Stack. https://healthnews.com/longevity/longevity-supplements/the-insiders-guide-to-bryan-johnsons-supplement-stack/. (5) A Redditor Tried All of Billionaire Bryan Johnson’s (Many) Supplements .... https://honehealth.com/edge/lifestyle/bryan-johnson-supplement-stack/. (6) What supplements does Bryan Johnson take? - Perpetua Life Blog. https://blog.perpetua.life/what-supplements-does-bryan-johnson-take/. (7) Step 1 | Step 2 | Step 3 — blueprint. https://protocol.bryanjohnson.com/Step-1-Step-2-Step-3. (8) Blueprint – Blueprint Bryan Johnson. https://blueprint.bryanjohnson.com/. (9) Bryan Johnson Takes 100 Pills a Day - HealthNews. https://healthnews.com/news/effect-of-taking-100-pills-a-day-like-bryan-johnson/. Based on the information provided, there is no direct mention of foods or herbs that are high in Calcium Alpha-Ketoglutarate (Ca-AKG). However, we can infer from the context that certain diets may include foods that are rich in antioxidants or minerals that could contribute to the overall health benefits associated with Ca-AKG. Here is a structured breakdown of the relevant information regarding Ca-AKG and its potential sources: Calcium Alpha-Ketoglutarate: Is an essential compound that regulates energy metabolism, DNA expression, and inflammation response8. Has been shown to improve kidney function and nutrition in patients with chronic renal failure6. Combines the mineral calcium with alpha-ketoglutarate, a molecule important in metabolic pathways9. Potential Sources of Ca-AKG: From the provided sources, we can deduce that certain lifestyle choices or supplementations may be rich in Ca-AKG. These include: Dietary Supplements: Maxx Herb Calcium AKG2 Liposomal Calcium AKG Supplement5 Calcium Alpha-Ketoglutarate powder7 Natural Foods: Oily fish, such as wild salmon, sardines, and tuna, which are rich in the antioxidant astaxanthin1. Red marine algae, from which astaxanthin is derived1. Herbal Products: Not explicitly mentioned in the sources, but it is worth noting that certain herbs like black cohosh have been searched alongside Ca-AKG, suggesting potential synergies in natural health products3. It is important to note that while these sources suggest potential ways to incorporate Ca-AKG into one's diet or supplement regimen, they do not provide specific details about the concentration of Ca-AKG in these foods or herbs. Therefore, individuals interested in maximizing their intake of Ca-AKG should consider targeted supplementation or consult with healthcare providers for personalized nutritional advice. Foods and herbs that contain Nordihydroguaiaretic Acid (NDGA) include: Chaparral Tea: Derived from the leaves and twigs of the creosote bush (Larrea tridentata), chaparral tea is a source of NDGA 345. Other Herbal Products: While specific details are not provided, it can be inferred from the context that NDGA is found in various herbal products, including those mentioned in the sources 126. It's important to note that while NDGA is found in these plants, the levels and bioavailability may vary depending on the species and part of the plant used. For instance, the concentration of NDGA in L. tridentata leaves ranges from 5% to 10% of dry weight 1. Additionally, NDGA has been recognized for its antioxidant and free radical scavenging properties, which may contribute to its health benefits 23. For further reading on the subject and to gain a deeper understanding of NDGA and its potential health benefits, you can refer to the following sources: "Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata): Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin" (PubMed Central ID: PMC3138708) 2. "Chaparral: Benefits, Uses, and Side Effects" (WebMD) 7. "Nordihydroguaiaretic Acid: A Review of Its Numerous and Potential Health Benefits" (ResearchGate) 6. To determine which foods and herbs raise nicotinamide adenine dinucleotide (NAD) levels, we must consider those that are rich in vitamin B3 (niacin) and tryptophan, as these nutrients are essential for the production of NAD+ 1. Based on the information provided, here is a list of foods and herbs that can naturally boost NAD levels: Foods: Fish: Particularly rich in niacin and tryptophan, with tuna, anchovies, and salmon being exceptional sources 1. Dairy Milk: Contains nicotinamide riboside, a form of niacin that is a major NAD+ precursor 1. Green Vegetables: Such as asparagus and peas, which can naturally increase NAD+ levels in the body 3. Mushrooms: Certain mushrooms are noted to be good sources of NAD+ 3. Whole Grains: May contribute to NAD+ levels due to their content of vitamin B and minerals . Raw Foods: Those that contain vitamin B, such as avocados, steamed fish, and peanuts, are thought to help boost NAD+ levels . Herbs: While specific data on the NAD+ content of herbs is not provided in the sources, it is worth noting that herbal teas may contain various nutrients that could influence NAD+ levels indirectly. For instance, herbs rich in vitamin B3 or tryptophan might support the body's natural production of NAD+ through their nutrient content. Additionally, certain herbal practices, such as heat shock and saunas, can increase NAD+ levels by increasing blood flow to the skin and potentially enhancing the conversion rate of NADH to NAD+ 2. In summary, the foods and herbs that can raise NAD levels are those that are rich in vitamin B3 and tryptophan, as these nutrients are crucial for the synthesis of NAD+ in the body. It's also important to note that while some foods and herbs can support NAD+ levels, others, such as excessive carbohydrate intake or sedentary lifestyle, can lead to an excess production of NADH, which can result in a decrease in NAD+ levels 2. Therefore, it's not just about consuming NAD+ rich foods but also about maintaining a balance and a healthy lifestyle that supports the proper functioning of NAD+ related biological processes.